Lab Key visual

Research in our group focuses on the development of spectroscopic methods for molecular and materials sciences that allow to characterize complex systems that, to date, have been inaccessible with conventional analytical tools. We use the spectroscopic methods we develop to solve problems in complex systems such as enzymes, catalytic nanoparticles, pharmaceutical compounds, and live model organisms.

The group has a state-of-the-art experimental research program for the visualization of the structure and dynamics of the constituents of molecules and materials by developing new nuclear magnetic resonance spectroscopy methods.

How?

Our research is centred around the question “How?”.

More specifically “How can we see the structure and dynamics of the invisible species that make up molecules and materials?” We use Nuclear Magnetic Resonance to find ways to do that, and our everyday tasks involve working out how the dynamics of nuclear spins can be controlled in new ways to report on systems of ever increasing complexity. Those systems range across disciplines from genetically modified nematode worms, through enzymes, to nanoparticle based catalysts and pharmaceutical formulations.

Our work is centred on new experimental observations. We invent and then implement new NMR experiments using state-of-the-art technology. Not only do we use fundamental concepts in spectroscopy and NMR spectrometers to discover structure and dynamics, but we are increasingly developing strategies that combine NMR with quantum chemical calculations (DFT) on the one hand, or sophisticated multivariate statistical data analysis on the other hand, to achieve our goals.

NEWS

EPFL installs world-unique NMR system

EPFL’s Institute of Chemical Sciences and Engineering (ISIC) has installed an NMR system with the highest sensitivity and resolution in the world.

Lyndon Emsley wins the 2015 Bourke Award

Awarded for the development of experimental methods that have transformed the field of solid-state NMR and enabled new applications across chemistryAwarded for the development of experimental methods that have transformed the field of so

Waking proteins up from deep sleep to study their motions

In order to carry out their functions, proteins need to move. Scientists at EPFL have developed a new technique to study motions in proteins with unprecedented accuracy. The method, which is based on NMR, freezes proteins down to immobil

Latest publications

2018

J. Viger-Gravel; Schantz Anna; A. C. Pinon; A. J. Rossini; Schantz Staffan et al. : Structure of Lipid Nanoparticles Containing siRNA or mRNA by Dynamic Nuclear Polarization-Enhanced NMR Spectroscopy; The Journal of Physical Chemistry. 2018-02-22. DOI : 10.1021/acs.jpcb.7b10795.
D. J. Kubicki; D. Prochowicz; A. Hofstetter; M. Saski; P. Yadav et al. : Formation of Stable Mixed Guanidinium–Methylammonium Phases with Exceptionally Long Carrier Lifetimes for High-Efficiency Lead Iodide-Based Perovskite Photovoltaics; Journal of the American Chemical Society. 2018-02-21. DOI : 10.1021/jacs.7b12860.
L. Emsley : Solid-state NMR approaches to inorganic materials: From lead-halide perovskites to gallium phosphide. 2018.
F. Paruzzo; G. Stevanato; M. Halse; J. Schlagnitweit; D. Mammoli et al. : Refocused linewidths less than 10 Hz in H-1 solid-state NMR; J. Magn. Reson.. 2018. DOI : 10.1016/j.jmr.2018.06.001.
E. Pump; A. Bendjeriou-Sedjerari; J. Viger-Gravel; D. Gajan; B. Scotto et al. : Predicting the DNP-SENS efficiency in reactive heterogeneous catalysts from hydrophilicity; Chem. Sci.. 2018. DOI : 10.1039/c8sc00532j.